Vitamins B1, B6 and B12 – What are they for? What are its benefits?

Vitamins, like all other nutrients, are essential for the body to function well both in the short and long term. Each one of them individually fulfils a number of specific functions, but we must not forget that together they also carry out an indispensable task in order to enjoy a good state of physical and mental health. In this case, we will discuss what vitamin B1, B6 and B12, three of the most important nutrients for our body, provide us together.

What are vitamin B1, B6 and B12 complexes for?

Next we will explain everything related to these three vitamins and what it is, what they are for and what they serve and what they contribute to the body and our health.

Major health benefits

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The contribution of vitamin B to treat pain in humans has been studied for many years. In general terms, the combination B1, B6 and B12 has a high analgesic efficacy, which considerably calms this type of discomfort.

These three vitamins play a key role in the treatment of pain, especially when pain has an inflammatory origin. In this case, medical professionals prescribe a vitamin B1-B6-B12 complex; combined with analgesic drugs, it is very helpful to calm the symptoms, some of the best known are the over-the-counter drugs called Hydroxyl and Benexol.

These three micronutrients used together have a marked antinociceptive effect on acetic acid and formalin administration tests. Both are models used in medicine to characterize analgesic drugs. Furthermore, it has been shown that taking a vitamin complex with this composition is much more beneficial than taking each of these vitamins individually.

The effect of the three nutrients in pain processes with another origin, such as neuropathic, has also been studied. Taking a multivitamin B1-B6-B12 complex for one week reduced levels of allodynia and hyperalgesia, while improving nerve conduction speed. However, if these vitamins are taken separately, only the nutrient B6 slightly improves the latter aspect, although in no case does it reach the level of the complex combining the three vitamins.

How do we enjoy this vitamin complex?

Vitamins b1 b6 b12 to treat pain

There are many drugs and medications with vitamin B12 that include this composition; in fact, it is one of the most widely used vitamin complexes in the world.

The composition can vary in amounts of each vitamin but these are vitamin B1 (thiamine), B6 (pyridoxine) and B12 (cyanocobalamin), which actively participate in a wide range of body processes.

Thus, the active principles are:

  • Thiamine hydrochloride (vitamin B1)
  • Pyridoxine hydrochloride (vitamin B6)
  • Cyanocobalamin (vitamin B12)

The rest of the components will vary from brand to brand but usually include opovidone, sodium carboxymethyl starch (potato), hypromellose, titanium dioxide, sodium stearyl fumarate, modified corn starch, citric acid, trisodium citrate, silicon dioxide, natural wax, glycerol, medium chain triglycerides and carm acid.

Any vitamin complex of this type is indicated both to prevent and to treat deficiencies of the aforementioned. The lack of these nutrients together is manifested in back pain, loss of appetite or continuous headaches. If you have a lack of any of them, the symptoms will be very varied. We have already talked about vitamin B12 deficiency in another post.

The complex is suitable for adults and adolescents over 14 years of age. Of course, the intake also differs with each type of complex, although it is usual to take one tablet a day orally. In the vast majority of cases, treatment should not exceed two weeks; however, the physician may assess that the duration of treatment is longer depending on the needs of each patient.

Warnings and precautions regarding the use of combined B1, B6 and B12

There are certain population groups for which taking this drug is not appropriate:

  • People allergic to vitamins B1, B6 and B12 or cobalt
  • Levodopa supplementation for Parkinson’s patients also is not available
  • Or those with Leber’s disease or tobacco amblyopia
  • Taking this complex is also not recommended for patients with kidney or liver disease
  • Not for pregnant women and children under 14 years of age


There are a number of precautions to consider:

  • On the one hand, it is essential to adhere to the period of treatment indicated by the doctor; prolonged intake can lead to episodes of dependence.
  • On the other hand, if a given patient suffers from a blood disease, such as anaemia, it is important to perform a series of tests before taking any such complex.
  • In addition, prolonged exposure to the sun should be avoided during treatment because the chances of skin lesions are high.

Vitamin Complex b1 b6 b12 for health

Drugs not allowed

If a patient is taking any of the following medications, you should tell your doctor:

  • Levodopa
  • Phenobarbital
  • Altetamine
  • Amiodarone
  • Neuromuscular blocker medications
  • 5-Fluorouracil
  • Peniciliamine
  • Hydralazine
  • Cyclosporine

Side effects

Taking a combination of these types can lead to a series of adverse effects and 1 out of 100 people suffers from the following symptoms:

  • Nausea
  • Vomiting
  • Headache
  • Sleepiness
  • Numbness of arms and legs
  • Skin rashes
  • Hypersensitivity

Other reported cases, although the frequency is not known and much less frequent, are digestive discomfort, diarrhea, loss of appetite, skin lesions, dizziness, insomnia and tingling in extremities.

Other main B-complex vitamins

Vitamins B1, B6 and B12 are among the most important of the vitamin B complex, but there are also other vitamins that fulfil a significant number of functions in the body and therefore must be taken into account and consumed daily. The main ones are as follows:

  • Vitamin B2: It is one of the most important nutrients for good vision. It also helps keep the skin healthy. One of its most important functions is the formation of red blood cells, which carry oxygen to the cells through the blood.
  • Vitamin B3: An indispensable vitamin for the cells of the human body. It is especially important for the health of the skin, as well as to keep the muscular system in perfect condition. It is also one of the most important nutrients to maintain mental agility.
  • Vitamin B5: Helps to metabolize food and regulate the nervous system. It is also a nutrient that actively participates in the generation of skin cells.
  • Vitamin B9: One of the most important vitamins in the body, especially during pregnancy. In addition, the cardiovascular system is extremely beneficial for health.

In addition, there are many other semivitamins and similar nutrients that are related to this complete complex, allowing us to reaffirm their importance.

The B-vitamin complex is undoubtedly essential for good physical and mental health. Broadly speaking, its general function is related to energy production, but there are many other important functions of the vitamins that make it up, such as red blood cell production, DNA and RNA formation, as well as strengthening the nervous system and maintaining cardiovascular health.

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Do you know the benefits and co-indications of B1+B6+B12 complex? Have you ever taken it? Tell us about your experiences, I am sure you will help other people to solve their doubts!

If you found it helpful or have any questions, please comment and share, thank you! 😉

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