What is hydroxocobalamin and what is it for?

Hydroxocobalamin is a form of vitamin B12, water-soluble of bacterial origin and created in a laboratory to replace the lack of cobalamin and allow our body to carry out its own functions. At the molecular level, it should be pointed out that hydroxycobalamin is created by joining the sixth valence of B12 with an element of the hydroxyl group. It fulfills three functions that are absolutely essential for the body to function properly:

  • On the one hand, it plays a leading role in the body’s production of red blood cells; this is very important because it is the red blood cells that carry oxygen to the cells through the blood.
  • On the other hand, it is also in charge of keeping the nervous system in perfect condition.

It also has some additional functions such as the metabolism of fats and carbohydrates in the body.

Hydroxocolamine – Is it natural or artificial?

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Chemical compound
Molecular formula of hydroxocobalamin

  • ✅ Molar mass: 1346.37 g/mol
  • ✅ Number CAS: 13422-51-0
  • ✅ Other names: Vitamin B12, hydroxocobalamine
  • Semi-developed formula: C62H89CoN13O15P

Cobalamin is mainly found in foods of animal origin, such as dairy products, eggs, some fish such as salmon, sardine or herring, beef or chicken breast or livers, among others.

There are also plant foods that contain it, although the amount is so minimal that it does not serve to satisfy the demand of our organism. That is why vegan or vegetarian people who do not take supplements in one of its forms are at great risk of suffering from lack of this nutrient.

However, as we have indicated, hydroxocobalamin is artificial. It is found in pharmacological products and dietary supplements.

Vitamin B12 deficiency – How can hydroxocobalamin help?

Let’s see now what kind of people can suffer from vitamin B12 deficiency and therefore require treatment of hydroxocobalamin or B12 in any other form.

  • Pathologies: There are certain pathologies, or digestive diseases, that do not allow the body to properly absorb this vitamin. This is the case for people with coeliac condition or Crohn’s disease, among others. To avoid having low levels, these patients should take supplements of this nutrient that do not require absorption by the body, i. e. that they come into contact with the bloodstream directly. It must be prescribed by your doctor.
  • People over 50 years of age: The case is quite similar to the previous one, although for a different cause. These people’s stomach has lost absorption capacity simply because of age. They should also be supplemented according to medical advice.
  • Vegan or vegetarian people: As we have mentioned, people who do not eat animal foods and do not take supplements have a very high probability of suffering from lack of this nutrient.

If any of these people suffer at any time from nutrient deficiency, they should be quickly supplemented; perhaps with hydroxycobalamin or, as we have mentioned, with another form of B12, such as cyanocobalamin (the most recommended form of supplementation).

The symptomatology, if any, is quite clear. Generally, 100% of patients who suffer from it suffer from a feeling of fatigue and despondency for no apparent reason. In addition, there are other symptoms such as disorientation, numbness and tingling in the extremities, arms and legs. There are also some mental symptoms, such as irritation.

Hydroxocobalamin treatment for people with B12 deficiency

We will now look at all aspects of hydroxocobalamin treatment to improve our health due to deficiencies in optimal blood B12 levels:


First of all, it is important to note that the form of administration of this drug is, in the vast majority of cases, by mouth; it can be either directly in pill form, or in powder form dissolved in water.

In certain cases, the medical staff may recommend administration by intravenous or intramuscular injections. This is not the most common, but it happens often, with both positive and negative consequences.

Its use is indicated for people with:

  • Pernicious anemia
  • Malabsorption syndromes 
  • Crohn’s disease
  • Gastrectomy
  • Strict vegetarian people.
  • Metabolic disorders
  • Patients with methylmalonic acidemia with or without homocystinuria


The recommended dose should be prescribed by a doctor. In general, for vitamin B12 deficiency, a dose of hydroxocobalamin of 1000 micrograms per day is prescribed for 5 or 6 days.


There are certain people for whom this medicine is totally prohibited. This is the case for those patients who have anemia caused by iron deficiency, hypertensive people, patients with some type of kidney disease, pregnant or nursing women, and patients with megaloblastic anemia.

Side effects

Hydroxycobalamin is a drug and therefore, like any other drug, has certain side effects. It should be noted that these occur on rare occasions:

  • Chest pain or pressure
  • Dizziness
  • Tremors
  • Tingling in extremities

There may be more severe warning signs that require medical attention, such as diarrhea, pain at the injection site, or severe headache.

Commercial name

  • Megamilbedoce B12
  • Presentation: Injections of 10.000 mcg
  • Packaging: 10 ampoules of 2 ml


In this way, it is clear what hydroxocobalamin is and what it is for: a treatment for vitamin B12 deficiency. It is worth noting that the lack of this nutrient is a serious disease that can have catastrophic health consequences in the medium and long term, especially in older people (even dementia due to loss of brain mass) and for pregnant women and their fetuses.

To avoid this kind of situation, the best thing is to live a healthy and balanced lifestyle, with a rich and varied diet of both plant and animal food. In addition, to make sure 100% of your body gets the dosage of cobalamin it needs to function properly, supplements are more than recommended. B12 that you don’t need will be flushed out of your urine, so you don’t have to be treated with hydroxycobalamin.

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Did you know the characteristics and properties of hydroxocobalamin? Have you ever had to treat yourself with this medicine? Tell us about your experience and share it with other members of the community!

If you found it helpful or have any questions, please comment and share, thank you! 😉

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What is【HYDROXOCOBALAMIN】? Benefits and Side Effects ▷B12
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