What is adenosylcobalamin and what is it for?

Vitamin B12 is an essential nutrient for the proper functioning of the body. So much so that its complexity leads it to find itself in different forms, one of them, adenosilcobalamin or cobamamide, of which we are going to speak in this article, what are its main benefits, uses, functions, what it is and what it can serve us for.

Adenosylcobalamin (5′ deoxyadenosylcobalamin) is one of the two natural forms in which cobalamin is found in our body; the other is methylcobalamin. However, it is worth mentioning that they are also found today in pharmacological products.

What is adenosilcobalamin? Main functions

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This is also the co-factor of methylmalonyl coenzyme A mutase. This is a thioester (compounds resulting from the union of a sulphur with an acilous group with the general formula R-S-CO-R’) that acts as an intermediary in the synthesis of several organic compounds, besides being essential to assimilate carbon in a non-toxic way.

This means that adenosylcobalamin, in addition to having its functions as a B12 form, is necessary for the functions of methylmalonil coenzyme A mutase to be performed. On the other hand, we have to indicate that this form of cobalamin, also called B12c, is found in food, being, along with hydroxocobalamin, the most common.

Chemical compound
Formula of the adenosylchobalamin or cobamamide molecule

  • ✅ Molar mass: 1579,49 g/mol
  • ✅ Number CAS: 13870-90-1
  • ✅ Other names: Cobamamide, dibencozide
  •  Semi-developed formula: C72H100CoN18O17P

This form of vitamin B12 is essential in the formation of the myelin layer, so it is very important in the central nervous system. It also plays a very important role in transforming hydrates into energy in the body.

This is why people who have lack of this nutrient usually present damage to the central nervous system; some of the first symptoms are numbness of the extremities and tingling in them. Weakness and exhaustion are also common, both physically and mentally.

What other forms of vitamin B12 can we find?

The most common forms of cobalamin are hydroxocobalamin, which we find both naturally and artificially, methylcobalamin (B12m), available in a multitude of foods and “copied” for sale in pharmacological products, adenosylcobalamin (B12c), which is the same thing and cyanocobalamin, which is only artificial and is formed with activated carbon, containing a trace.

There are other less common forms, such as sulfitocobalamin, which is included in canned foods; some are even in sewer sludge, animal feces, bacteria, etc. In this case, they do occur with the nucleotide changed.

On the other hand, it should also be noted that when our body absorbs vitamin B12, it transforms it into methylcobalamin, which is the way in which the nutrient circulates through the blood. It also transforms it into cobalamine-adenosyl, which is the way it is stored in the liver.

Are there adenosylcobalamin supplements?

There are supplements in this form of B12. These are mainly indicated for people with kidney problems as well as for those in which adenosil functions do not function properly. In general, the most commonly used supplements are methylcobalamin, also advised in particular situations, and cyanocobalamin, which is the most common formula and generally the most beneficial. Also the hydroxocobalamin formulation, much more specific and that is shipped mainly as injectable in ampoule.

  • Adenosylcobalamin supplements: For people with kidney disease
  • Methylcobalamin supplements: Ideal for those with B12 absorption problems
  • Cyanocobalamin Supplements: The most common of all and at the end of the day, the most advisable (vegans and vegetarians)
  • Hydroxocobalamin Supplements: This form is exclusively designed for B12 injectables

What side effects are there from having a vitamin B12 deficiency?

Risks and symptoms of vitamin b12 deficiency

Its deficiency is a relatively serious pathology that can occur mainly for two reasons:

On the one hand, that not enough foods rich in this nutrient and/or supplements are consumed. This is mainly found in foods of animal origin, so vegans and vegetarians or those on a low-calorie diet who do not take supplements may suffer from a lack of this nutrient.

On the other hand, people who are either due to their age or due to a disease of the digestive system, are not able to properly absorb the nutrients in their bodies.

Some of the most common symptoms of this pathology are anaemia, drowsiness, tiredness, arrhythmia, tingling in extremities… In the most severe cases, in which vitamin B12 deficiency is prolonged over time, a loss of brain mass can occur, causing dementia and dysfunction of various mental processes.


Adenosylcobalamin is one of the most common forms in which B12 is found; we take it in food and it is also the result of a process of transformation of other forms of the vitamin.

It has also been chemically formulated to be able to obtain it artificially, serving as a treatment for certain pathologies related to the functions it performs in the body.

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Did you know the different forms B12 can take? And its uses and main functions? If you have any questions or would like to give us your opinion, please let us know in the comments!

If you found it helpful or have any questions, please comment and share, thank you! 😉

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What is【ADENOSYLCOBALAMIN】? Benefits and Side Effects ▷B12
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